Publications

  1. Goldberg, E.L. Integration of immune-metabolic signals to preserve healthy agingTranslational Medicine of Aging epub July 24, 2020
  2. Stubbs, B.J., Koutnik, A.P., Goldberg, E.L., Upadhyay, V., Turnbaugh, P.J., Verdin, E., Newman, J.C. (2020) Investigating ketone bodies as immunometabolic countermeasures against respiratory viral infectionsCell Med 1, 1-23 Published online July 15, 2020.
  3. Goldberg, E.L., Shaw, A.C., Montgomery, R.R. How Inflammation Blunts Innate Immunity in Aging. Weinberger B (ed): Vaccines for Older Adults: Current Practices and Future Opportunities. Interdiscip Top Gerontol Geriatr. 2020, vol 43, pp 1–17 PMID: 32294641
  4. Goldberg, E.L., Shchukina, I., Asher, J.L., Sidorov, S., Artyomov, M.N., Dixit, V.D. (2020) Ketogenesis activates metabolically protective γδ T cells in visceral adipose tissue. Nature Metabolism Published online January 20, 2020.
  5. Goldberg, E.L., Molony, R.D., Kudo, E., Sviatoslav, S., Kong, Y., Dixit, V.D., Iwasaki, A. (2019) Ketogenic diet activates protective γδ T cell responses against influenza virus infection. Science Immunology 2019 Nov 15;4(41). doi: 10.1126/sciimmunol.aav2026. PMID: 31732517
  6. Camell C.D., Günther P., Lee A., Goldberg E.L., Spadaro O., Youm Y.H., Bartke A., Hubbard G.B., Ikeno Y., Ruddle N.H., Schultze J., Dixit V.D. Aging Induces an Nlrp3 Inflammasome-Dependent Expansion of Adipose B Cells That Impairs Metabolic Homeostasis. Cell Metab 2019 Dec 3;30(6):1024-1039.e6. doi: 10.1016/j.cmet.2019.10.006. PMID: 31735593
  7. Goldberg, E.L., Dixit, V.D. Bone Marrow: An Immunometabolic Refuge during Energy Depletion. Cell Metab. 2019 Oct 1;30(4):621-623. PMID: 31577929
  8. Camporez J.P., Lyu K., Goldberg  E.L., Zhang D., Cline G.W., Jurczak M.J., Dixit V.D., Petersen K.F., Shulman G.I. Anti-inflammatory effects of estrogen mediate the sexual dimorphic response to lipid-induced insulin resistance. J Physiol. 2019 June 17. PMID: 31206703
  9. Camell CD, Sander J, Spadaro O, Lee A, Nguyen KY, Wing A, Goldberg EL, Youm YH, Brown CW, Elsworth J, Rodeheffer MS, Schultze JL, Dixit VD. Inflammasome-driven catecholamine catabolism in macrophages blunts lipolysis during ageing. Nature. 2017 Oct 5;550(7674):119-123. PMID: 28953873
  10. Goldberg, E.L., Asher, J.L., Molony, R.D., Shaw, A.C., Zeiss, C.J., Wang, C., Morozova-Roche, L.A., Herzog, R.I., Iwasaki, A., Dixit, V.D. (2017) β-hydroxybutyrate deactivates neutrophil NLRP3 inflammasome to relieve gout flares. Cell Reports Feb 28;18(9):2077-2087. PMID 28249154
  11. Goldberg, E.L. and Dixit,V.D. (2017) Carnitine acetyltransferase (CRAT) expression in macrophages is dispensable for nutrient stress sensing and inflammation. Molecular Metabolism Jan 3;6(2):219-225. PMID 28180063
  12. Spadaro O., Goldberg, E.L., Camell, C.D., Youm, Y., Kopchick, J.J., Nguyen, K.Y., Bartke, A., Sun, L.Y., Dixit, V.D. (2016) Growth hormone receptor deficiency protects against age-related NLRP3 inflammasome activation and immune-senescence. Cell Reports Feb 23;14(7):1571-80. PMID 26876170
  13. Youm, Y.H., Nguyen, K.Y., Grant, R.W., Goldberg, E.L., Bodogai, M., Kim, D., D’Agostine, D., Planavsky, N., Lupfer, C., Kanneganti, T.D., Kang, S., Horvath, T.L., Fahmy, T.M., Crawford, P.A., Biragyn, A., Alnemri, E., Dixit, V.D. (2015) The ketone metabolite β-hydroxybutyrate blocks NLRP3 inflammasome-mediated inflammatory disease. Nat. Med. 21(3):263-9. PMID: 25686106.
  14. Goldberg, E.L. and Dixit, V.D. (2015) “Crowning” eosinophils in adipose tissue: does location matter? J Leukoc Biol. Oct;98(4):451-2. PMID 26429777
  15. Camell, C., Goldberg, E., Dixit, V.D. (2015) Regulation of Nlrp3 inflammasome by dietary metabolites. Seminars in Immunology 27:334-342. PMID 26776831
  16. Goldberg, E.L. and Dixit, V.D. (2015) Drivers of age-related inflammation and strategies for healthspan extension. Immunol Rev. 265(1):63-74. PMID 25879284
  17. Goldberg, E.L., Romero-Aleshire, M.J., Renkema, K.R., Ventevogel, M.S., Chew, W.M., Uhrlaub, J.L., Smithey, M.J., Limesand, K.H., Sempowski, G.D., Brooks, H.L., Nikolich-Zugich, J. (2015) Lifespan-extending calorie restriction or mTOR inhibition impair adaptive immunity of old mice by distinct mechanisms. Aging Cell. 14(1): 130-8. PMID: 25424641.
  18. Goldberg, E.L., Smithey, M.J., Lutes, L.K., Uhrlaub, J.L., Nikolich-Zugich, J. (2014) Immune memory-boosting dose of rapamycin impairs macrophage vesicle acidification and curtails glycolysis in effector CD8 cells, impairing defense against acute infections. J Immunol. 193(2): 757-63. PMID: 24913978.
  19. Kusne, Y.*, Goldberg, E.L.*, Parker, S.S., Hapak, S.M., Maskaykina, I.Y., Chew, W.M., Limesand, K.H., Brooks, H.L., Price, T.J., Sanai, N., Nikolich-Zugich, J., Ghosh, S. (2014) Contrasting effects of chronic, systemic treatment with mTOR inhibitors rapamycin and metformin on adult neural progenitors in mice. Age (Dordr). 36(1): 199-212. PMID: 23949159.                *Authors contributed equally
  20. Rudd, B.D., Venturi, V., Smith, N.L., Nzingha, K., Goldberg, E.L., Li, G., Nikolich-Zugich, J., Davenport, M.P. (2013) Acute neonatal infections ‘lock-in’ a suboptimal CD8+ T cell repertoire with impaired recall responses. PLoS Pathog. 9(9):e1003572. PMID: 24068921.